Vincent Rondeau

Oct 29, 2024 | science.org | Vincent Rondeau |Zhigang Li |Amy Baek |Xiaxi Dong

Editor’s summaryIn contrast to the neonatal mammalian heart, in which cardiomyocyte proliferation can enable complete repair, cardiomyocytes in the adult mammalian heart must be induced to reenter the cell cycle to achieve regeneration. Increases in purine availability are required to support enhanced DNA and RNA synthesis during proliferation, leading Li et al. to investigate how cardiac regeneration is affected by Adssl1, a critical enzyme in de novo purine synthesis.

Oct 29, 2024 | science.org | Vincent Rondeau |Zhigang Li |Amy Baek

AbstractA neuropeptide-receptor pair promotes the differentiation of TH1 cells and enhances their response to viral infection. SIGN UP FOR THE SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily Helper T cells, such as TH1, TH2, TH17, and Treg cells, are important in adaptive immune responses to infectious diseases, antitumor immunity, and autoimmunity.

Oct 29, 2024 | science.org | Vincent Rondeau |Zhigang Li |Amy Baek |Maria Kalogeraki

Editor’s summaryTruncations of the chemokine receptor CXCR4 prevent its internalization and cause WHIM syndrome, an inherited immunodeficiency characterized by increased numbers of myeloid cells in the bone marrow. In a mouse model of WHIM syndrome, Rondeau et al. found that a subset of multipotent progenitor cells that normally adopt a lymphoid fate were reprogrammed to instead adopt a myeloid fate.