Maria Kokkinaki

Jul 24, 2023 | nature.com | Nader Moazami |Karen Abou Khalil |Jacqueline Kim |Shivani Bisen |Ian Jaffe |Maria Kokkinaki | +3 more

AbstractGenetically modified xenografts are one of the most promising solutions to the discrepancy between the numbers of available human organs for transplantation and potential recipients. To date, a porcine heart has been implanted into only one human recipient. Here, using 10-gene-edited pigs, we transplanted porcine hearts into two brain-dead human recipients and monitored xenograft function, hemodynamics and systemic responses over the course of 66 hours.