Nader Moazami

May 17, 2024 | nature.com | Brian D. Piening |Maedeh Mohebnasab |Bo Xia |Jeffrey S. Stern |Weimin Zhang |Jacqueline I. Kim | +20 more

AbstractIn a previous study, heart xenografts from 10-gene-edited pigs transplanted into two human decedents did not show evidence of acute-onset cellular- or antibody-mediated rejection. Here, to better understand the detailed molecular landscape following xenotransplantation, we carried out bulk and single-cell transcriptomics, lipidomics, proteomics and metabolomics on blood samples obtained from the transplanted decedents every 6 h, as well as histological and transcriptomic tissue profiling.

Mar 6, 2024 | onlinelibrary.wiley.com | Jennifer D. Motter |Ian Jaffe |Nader Moazami |Deane Smith

DATA AVAILABILITY STATEMENT The data that support the findings of this study are available from the Scientific Registry of Transplant Recipients (SRTR). Restrictions apply to the availability of these data, which were used under license for this study. Data are available with the permission of the corresponding author and that of the SRTR. The internal NYU Langone data that support the findings of this study will be shared upon reasonable request to the corresponding author.

Jul 24, 2023 | nature.com | Nader Moazami |Karen Abou Khalil |Jacqueline Kim |Shivani Bisen |Ian Jaffe |Maria Kokkinaki | +3 more

AbstractGenetically modified xenografts are one of the most promising solutions to the discrepancy between the numbers of available human organs for transplantation and potential recipients. To date, a porcine heart has been implanted into only one human recipient. Here, using 10-gene-edited pigs, we transplanted porcine hearts into two brain-dead human recipients and monitored xenograft function, hemodynamics and systemic responses over the course of 66 hours.