
Karen Abou Khalil
Articles
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May 17, 2024 |
nature.com | Brian D. Piening |Maedeh Mohebnasab |Bo Xia |Jeffrey S. Stern |Weimin Zhang |Jacqueline I. Kim | +20 more
AbstractIn a previous study, heart xenografts from 10-gene-edited pigs transplanted into two human decedents did not show evidence of acute-onset cellular- or antibody-mediated rejection. Here, to better understand the detailed molecular landscape following xenotransplantation, we carried out bulk and single-cell transcriptomics, lipidomics, proteomics and metabolomics on blood samples obtained from the transplanted decedents every 6 h, as well as histological and transcriptomic tissue profiling.
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Jul 24, 2023 |
nature.com | Nader Moazami |Karen Abou Khalil |Jacqueline Kim |Shivani Bisen |Ian Jaffe |Maria Kokkinaki | +3 more
AbstractGenetically modified xenografts are one of the most promising solutions to the discrepancy between the numbers of available human organs for transplantation and potential recipients. To date, a porcine heart has been implanted into only one human recipient. Here, using 10-gene-edited pigs, we transplanted porcine hearts into two brain-dead human recipients and monitored xenograft function, hemodynamics and systemic responses over the course of 66 hours.
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