María Lara-Tejero

Mar 9, 2024 | biorxiv.org | Emily Guo |Steven Z. Chou |María Lara-Tejero |Jorge Galán

AbstractThe bacterial pathogen Salmonella spp. modulates cellular processes by delivering effector proteins through its type III secretion systems. Among these effectors, SipA facilitates bacterial invasion and promotes intestinal inflammation. The mechanisms by which this effector carries out these functions are incompletely understood although SipA's ability to modulate actin dynamics is central to some of these activities. Here we report the cryo-EM structure of SipA bound to filamentous actin.

Aug 28, 2023 | nature.com | Florian Schueder |María Lara-Tejero |Jun Liu

AbstractCell-intrinsic defences constitute the first line of defence against intracellular pathogens. The guanosine triphosphatase RAB32 orchestrates one such defence response against the bacterial pathogen Salmonella, through delivery of antimicrobial itaconate.