Marie-France Hivert

Jul 19, 2024 | nature.com | Zhila Semnani-Azad |Mario L. Morieri |John Dennis |Claudia Langenberg |Michèle Ramsay |Arun J Sanyal | +6 more

AbstractPrecision medicine should aspire to reduce error and improve accuracy in medical and health recommendations by comparison with contemporary practice, while maintaining safety and cost-effectiveness. The etiology, clinical manifestation and prognosis of diseases such as obesity, diabetes, cardiovascular disease, kidney disease and fatty liver disease are heterogeneous.

Oct 5, 2023 | nature.com | Robin Beaumont |Christopher Flatley |Marc Vaudel |JING CHEN |Gunn-Helen Moen |Line Skotte | +52 more

AbstractA well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1.

May 23, 2023 | nature.com | Jordi Merino |Hassan S Dashti |Marie-France Hivert |Richa Saxena

AbstractPrior research identified genetic variants influencing macronutrient preference, but whether genetic differences underlying nutrient preference affect long-term food choices is unknown. Here we examined the associations of polygenic scores for carbohydrate, fat, and protein preference with 12 months’ workplace food purchases among 397 hospital employees from the ChooseWell 365 study.

May 10, 2023 | nature.com | Pol Sole-Navais |Valgerdur Steinthorsdottir |Marc Vaudel |Julius Juodakis |JING CHEN |Triin Laisk | +40 more

Author notesAnubha Mahajan & Mark I. McCarthyPresent address: Genentech, South San Francisco, CA, USAThese authors contributed equally: Ge Zhang, Bo Jacobsson.

Apr 3, 2023 | nature.com | Pol Sole-Navais |Valgerdur Steinthorsdottir |Marc Vaudel |Julius Juodakis |JING CHEN |Triin Laisk | +40 more

AbstractThe timing of parturition is crucial for neonatal survival and infant health. Yet, its genetic basis remains largely unresolved. We present a maternal genome-wide meta-analysis of gestational duration (n = 195,555), identifying 22 associated loci (24 independent variants) and an enrichment in genes differentially expressed during labor. A meta-analysis of preterm delivery (18,797 cases, 260,246 controls) revealed six associated loci and large genetic similarities with gestational duration.