Yaw Asare

Aug 7, 2024 | nature.com | Jiayu Cao |Stefan Roth |Anna Kopczak |Yaw Asare |Marios K. Georgakis |Jack Green | +12 more

AbstractThe risk of early recurrent events after stroke remains high despite currently established secondary prevention strategies1. Risk is particularly high in patients with atherosclerosis, with more than 10% of patients experiencing early recurrent events1,2. However, despite the enormous medical burden of this clinical phenomenon, the underlying mechanisms leading to increased vascular risk and recurrent stroke are largely unknown.

Aug 6, 2024 | nature.com | Martin Dichgans |Yaw Asare

In a landmark study recently published in Nature,1 Wei and colleagues demonstrate that the activation of GSDMD by the cytosolic lipopolysaccharide (LPS) sensor caspase-11 triggers blood–brain barrier (BBB) breakdown upon LPS challenge independent of TLR4-induced cytokine release. Their work identifies the noncanonical inflammasome and GSDMD pore formation as a potential target for treating central nervous system (CNS) disorders associated with inflammatory BBB dysfunction.

Aug 5, 2024 | mdpi.com | Yaw Asare |Marios K. Georgakis

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