Mathias Wilhelm

Mar 15, 2024 | nature.com | Celina Tretter |Sebastian Lange |Johannes Untch |Gabriela Zuleger |Mathias Wilhelm |Katja Steiger | +13 more

Correction to: Nature Communications https://doi.org/10.1038/s41467-023-39570-7, published online 02 August 2023 With respect to the original “Data availability” statement, since the publication of this work, to ensure patient data privacy protection per request of the authors’ institute Technical University of Munich, the RNA-seq dataset from sorted CD8+ TILs originally deposited to the European Nucleotide Archive (ENA) with study accession number PRJEB61429 has been transferred to the...

Oct 30, 2023 | nature.com | Paul Brear |Larsen Vornholz |Stephanie Wilhelm |Patroklos Samaras |David Litchfield |Guillaume Médard | +4 more

AbstractMedicinal chemistry has discovered thousands of potent protein and lipid kinase inhibitors. These may be developed into therapeutic drugs or chemical probes to study kinase biology. Because of polypharmacology, a large part of the human kinome currently lacks selective chemical probes. To discover such probes, we profiled 1,183 compounds from drug discovery projects in lysates of cancer cell lines using Kinobeads.

Aug 2, 2023 | nature.com | Sebastian Lange |Mathias Wilhelm |Katja Steiger |Sebastian Ochsenreither |Sebastian Bauer |Melanie Boerries | +13 more

Human studyThe study was approved by the institutional review boards (Ethics Commission of the Medical Faculty of Technical University Munich (protocol 193/17S) and Ethics Committee of the Medical Faculty of Heidelberg University (protocol S-206/2011)) and all patients provided written informed consent under these protocols. The study was conducted in accordance with the Declaration of Helsinki.