Katja Steiger

Jul 10, 2024 | nature.com | Sainitin Donakonda |Jitao Zhang |Hannah Wintersteller |Martin Feuerherd |Juliane Siebourg-Polster |Carolin Mogler | +24 more

AbstractChronic hepatitis B virus (HBV) infection affects 300 million patients worldwide1,2, in whom virus-specific CD8 T cells by still ill-defined mechanisms lose their function and cannot eliminate HBV-infected hepatocytes3,4,5,6,7. Here we demonstrate that a liver immune rheostat renders virus-specific CD8 T cells refractory to activation and leads to their loss of effector functions.

Mar 15, 2024 | nature.com | Celina Tretter |Sebastian Lange |Johannes Untch |Gabriela Zuleger |Mathias Wilhelm |Katja Steiger | +13 more

Correction to: Nature Communications https://doi.org/10.1038/s41467-023-39570-7, published online 02 August 2023 With respect to the original “Data availability” statement, since the publication of this work, to ensure patient data privacy protection per request of the authors’ institute Technical University of Munich, the RNA-seq dataset from sorted CD8+ TILs originally deposited to the European Nucleotide Archive (ENA) with study accession number PRJEB61429 has been transferred to the...

Aug 4, 2023 | nature.com | Fei Wang |Katja Steiger

AbstractAlthough it has been established that cannabidiol (CBD), the major non-psychoactive constituent of cannabis, exerts antitumoral activities, the exact mechanism(s) via which tumor cells are killed by CBD are not well understood. This study provides new insights into the potential mechanisms of CBD-induced mutual antagonism of apoptosis and macroautophagy using wild type (HCT116 p53wt, LS174T p53wt), knockout (HCT116 p53−/−) and mutant (SW480 p53mut) human colorectal cancer cells (CRC).

Aug 2, 2023 | nature.com | Sebastian Lange |Mathias Wilhelm |Katja Steiger |Sebastian Ochsenreither |Sebastian Bauer |Melanie Boerries | +13 more

Human studyThe study was approved by the institutional review boards (Ethics Commission of the Medical Faculty of Technical University Munich (protocol 193/17S) and Ethics Committee of the Medical Faculty of Heidelberg University (protocol S-206/2011)) and all patients provided written informed consent under these protocols. The study was conducted in accordance with the Declaration of Helsinki.