Matthew Hall

Jul 15, 2024 | biorxiv.org | Caroline Colijn |Matthew Hall |Remco Bouckaert |Simon Fraser

AbstractWe introduce and apply Bayesian Reconstruction and Evolutionary Analysis of Transmission Histories (BREATH), a method to simultaneously construct phylogenetic trees and transmission trees using sequence data for a person-to-person outbreak. BREATH's transmission process that accounts for a flexible natural history of infection (including a latent period if desired) and a separate process for sampling.

Dec 14, 2023 | biorxiv.org | Chintan Soni |Noam Prywes |Matthew Hall |David Savage

AbstractUsing directed evolution, engineered aminoacyl-tRNA synthetases (aaRS) have been developed that enable co-translational incorporation of numerous noncanonical amino acids (ncAAs) into proteins in living cells. Until now, the selection of such novel aaRS mutants has relied on coupling their activity to the expression of a reporter protein with a selectable phenotype.