Matthew L. Senjem

Apr 2, 2024 | nature.com | Christopher Schwarz |Matthew L. Senjem |Dennis W. Dickson |Bradley F. Boeve

AbstractDementia with Lewy bodies (DLB) is a neurodegenerative condition often co-occurring with Alzheimer’s disease (AD) pathology. Characterizing white matter tissue microstructure using Neurite Orientation Dispersion and Density Imaging (NODDI) may help elucidate the biological underpinnings of white matter injury in individuals with DLB.

May 29, 2023 | nature.com | Emily S. Lundt |Christopher Schwarz |Matthew L. Senjem |Robert Reid |David S. Knopman |Prashanthi Vemuri | +3 more

In this work, we used an AFT model to study the association of individual adjustments in timing of AD and CVD biomarker progression. These findings are important in informing the proposed relationships between AD (defined as an accumulation of pathological aggregated amyloid and tau proteins) and small vessel cerebrovascular disease. The individual adjustments of AD biomarkers (amyloid and tau PET) and established CVD biomarkers (WMH and FA GCC) showed weak to no association.