Dennis W. Dickson

Jun 20, 2024 | nature.com | Özkan İş |Xue Wang |Joseph S. Reddy |Yuhao Min |Elanur Yilmaz |Prabesh Bhattarai | +19 more

AbstractTo uncover molecular changes underlying blood-brain-barrier dysfunction in Alzheimer’s disease, we performed single nucleus RNA sequencing in 24 Alzheimer’s disease and control brains and focused on vascular and astrocyte clusters as main cell types of blood-brain-barrier gliovascular-unit. The majority of the vascular transcriptional changes were in pericytes.

Apr 2, 2024 | nature.com | Christopher Schwarz |Matthew L. Senjem |Dennis W. Dickson |Bradley F. Boeve

AbstractDementia with Lewy bodies (DLB) is a neurodegenerative condition often co-occurring with Alzheimer’s disease (AD) pathology. Characterizing white matter tissue microstructure using Neurite Orientation Dispersion and Density Imaging (NODDI) may help elucidate the biological underpinnings of white matter injury in individuals with DLB.

Nov 2, 2023 | nature.com | Yuhao Min |Xue Wang |Joseph S. Reddy |Zachary Quicksall |Thuy Nguyen |Thụy Tường Nguyễn | +3 more

AbstractProgressive supranuclear palsy (PSP) is a neurodegenerative parkinsonian disorder characterized by cell-type-specific tau lesions in neurons and glia. Prior work uncovered transcriptome changes in human PSP brains, although their cell-specificity is unknown. Further, systematic data integration and experimental validation platforms to prioritize brain transcriptional perturbations as therapeutic targets in PSP are currently lacking.

Aug 8, 2023 | onlinelibrary.wiley.com | Shunsuke Koga |Nicholas Martin |Dennis W. Dickson

1 INTRODUCTION Artificial Intelligence (AI), specifically large language models (LLMs) like ChatGPT developed by OpenAI, demonstrate promising utility in healthcare applications, from clinical decision support to medical education. As of May 15, 2023, a PubMed search for the term “ChatGPT” yielded 420 manuscripts published in 2023 alone, reflecting the growing interest in AI-based models in healthcare.

Feb 20, 2023 | alzheimersweekly.com | B. K. Berger |Dennis W. Dickson

The strongest predictor of whether a man is developing dementia with Lewy bodies — the second most common form of dementia in the elderly — is whether he acts out his dreams while sleeping, Mayo Clinic researchers have discovered.