Maura Malpetti

Dec 19, 2023 | nature.com | David Whiteside |Maura Malpetti |George Savulich |P. Jones |Timothy Rittman |John O’Brien

AbstractThere is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical models and human in vivo and post mortem studies. Understanding the consequences of synaptic loss for network function is important to support translational models and guide future therapeutic strategies. To examine this relationship, we recruited 55 participants with syndromes associated with frontotemporal lobar degeneration and 24 healthy controls.

Nov 6, 2023 | n.neurology.org | Maura Malpetti |Gil D. Rabinovici

With the emergence of disease-modifying therapies for Alzheimer disease (AD), it is imperative that standardized approaches to interpret relevant biomarkers are validated and clinically available. [18F]-flortaucipir was the first PET tracer to show high affinity and selectivity for AD tau neurofibrillary tangles.