George Savulich

Oct 28, 2024 | nature.com | Stacey L. Kigar |Leonidas Chouliaras |Noah S. Shapiro |George Savulich |Kaj Blennow |Henrik Zetterberg | +2 more

AbstractThe innate immune system plays an integral role in the progression of many neurodegenerative diseases. In addition to central innate immune cells (e.g., microglia), peripheral innate immune cells (e.g., blood monocytes, natural killer cells, and dendritic cells) may also differ in these conditions. However, the characterization of peripheral innate immune cell types across different neurodegenerative diseases remains incomplete.

Dec 19, 2023 | nature.com | David Whiteside |Maura Malpetti |George Savulich |P. Jones |Timothy Rittman |John O’Brien

AbstractThere is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical models and human in vivo and post mortem studies. Understanding the consequences of synaptic loss for network function is important to support translational models and guide future therapeutic strategies. To examine this relationship, we recruited 55 participants with syndromes associated with frontotemporal lobar degeneration and 24 healthy controls.