P. Jones

Dec 19, 2023 | nature.com | David Whiteside |Maura Malpetti |George Savulich |P. Jones |Timothy Rittman |John O’Brien

AbstractThere is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical models and human in vivo and post mortem studies. Understanding the consequences of synaptic loss for network function is important to support translational models and guide future therapeutic strategies. To examine this relationship, we recruited 55 participants with syndromes associated with frontotemporal lobar degeneration and 24 healthy controls.