Maximilian Otto

Aug 22, 2024 | nature.com | Selene Lickfett |Agnieszka Rybak-Wolf |Carmen Menacho |Stephanie Le |Tancredi Massimo Pentimalli |Daniel Oehler | +14 more

AbstractExpansion of the glutamine tract (poly-Q) in the protein huntingtin (HTT) causes the neurodegenerative disorder Huntington’s disease (HD). Emerging evidence suggests that mutant HTT (mHTT) disrupts brain development. To gain mechanistic insights into the neurodevelopmental impact of human mHTT, we engineered male induced pluripotent stem cells to introduce a biallelic or monoallelic mutant 70Q expansion or to remove the poly-Q tract of HTT.

Feb 29, 2024 | nature.com | Andreas J. Müller |Jan Philipp Albrecht |Maximilian Otto |Gunar Fabig

AbstractVolume electron microscopy is the method of choice for the in situ interrogation of cellular ultrastructure at the nanometer scale, and with the increase in large raw image datasets generated, improving computational strategies for image segmentation and spatial analysis is necessary.

Jun 8, 2023 | biorxiv.org | Maximilian Otto |Florian David |Verena Siewers |Michael Gossing

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May 18, 2023 | biorxiv.org | Yasaman Dabirian |Florian David |Verena Siewers |Maximilian Otto

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