Megen C Wittling

3 weeks ago | biorxiv.org | Megen C Wittling |Megan Wyatt |Aubrey S. Smith |Anna Cole

AbstractAdoptive transfer of neoantigen-reactive T lymphocytes mediates potent responses against solid tumors in patients while often limiting toxicity to normal tissues; however, the mechanisms governing the trafficking, activation, and superior antitumor function of infused T cells remain unknown. Using a clinically relevant TCR-transgenic T cell therapy model, we examined CD8 T cell responses to melanoma expressing either wild-type or mutated antigen.

Nov 1, 2024 | jitc.bmj.com | Anna Cole |Hannah M. Knochelmann |Megan Wyatt |Megen C Wittling

http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial.

Oct 31, 2024 | jitc.bmj.com | Megan Wyatt |Hannah M. Knochelmann |Anna Cole |Megen C Wittling

http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial.

Aug 16, 2024 | mdpi.com | Megen C Wittling |Anna Cole |Brianna Brammer |Kailey G. Diatikar

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Jun 1, 2024 | jitc.bmj.com | Megen C Wittling |Hannah M. Knochelmann |Megan Wyatt |Anna Cole

MethodsThese studies were conducted using C57BL/6 and TRP-1 TCR transgenic mice (Rag−/− BWTRP-1 TCR) purchased from Jackson Laboratories. The TRP-1 TCR transgenic mice (Rag−/− BWTRP-1 TCR) are bred in-house at Emory University, while C57BL/6 mice were purchased from the Jackson Laboratory, and tumor experiments are conducted with mice ages 6–10 weeks.