Melita B. Irving

Sep 14, 2023 | nature.com | Massimo Andreatta |Cristina Lopez-Rodriguez |George Coukos |Melita B. Irving |Santiago J Carmona |Werner Held | +2 more

AbstractPersistent exposure to antigen during chronic infection or cancer renders T cells dysfunctional. The molecular mechanisms regulating this state of exhaustion are thought to be common in infection and cancer, despite obvious differences in their microenvironments.

Aug 7, 2023 | onlinelibrary.wiley.com | Sarah Ash |Melita B. Irving

1 INTRODUCTION CD8+ T cells play a critical role in controlling solid cancers but to do so they must successfully reach and penetrate the tumor, expand and persist within the hostile and suppressive TME. They must also specifically recognize tumor cells and serially kill them while sparing healthy tissues.