Meng Cui

Jan 15, 2025 | mdpi.com | Shuai Yang |Meng Cui |Chen Li |Ming Qiu

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Aug 4, 2024 | nature.com | Kevin Knight |Brian Krumm |W. Grant Ludlam |Meng Cui |Tyler J. Lefevre |Wenyuan Wei | +9 more

AbstractMany neurotransmitter receptors activate G proteins through exchange of GDP for GTP. The intermediate nucleotide-free state has eluded characterization, due largely to its inherent instability. Here we characterize a G protein variant associated with a rare neurological disorder in humans. GαoK46E has a charge reversal that clashes with the phosphate groups of GDP and GTP.

Feb 2, 2023 | newsbreak.com | Meng Cui

Alexander Spira, MD, PhD, FACP, discusses osimertinib-relapsed disease and its sensitivity to EGFR or MET inhibition. Alexander Spira, MD, PhD, FACP, director of the Virginia Cancer Specialists Research Institute, discusses osimertinib (Tagrisso)-relapsed disease and its sensitivity to EGFR or MET inhibition. Currently, there are not many treatment options for patients... 19 HOURS AGO