Mengting Chen

Oct 9, 2024 | nature.com | Mengting Chen |Peijie Zhou |Suoqin Jin |Mei Wang |Qing Nie |Ben Wang | +1 more

AbstractRosacea is a chronic inflammatory skin disorder, whose underlying cellular and molecular mechanisms remain obscure. Here, we generate a single-cell atlas of facial skin from female rosacea patients and healthy individuals. Among keratinocytes, a subpopulation characterized by IFNγ-mediated barrier function damage is found to be unique to rosacea lesions. Blocking IFNγ signaling alleviates rosacea-like phenotypes and skin barrier damage in mice.