Mei Wang

Jan 4, 2025 | mdpi.com | Mei Wang

2. Results 2.1. Characterization of Ca-Mg@MSNsThe MSN subs were dispersed in different concentrations of CaCl2 and MgCl2 solutions, keeping Ca2+:Mg2+ = 1:1, and determined the particle size, the PDI, and potential. The results are shown in Figure 1a. The particle sizes of Ca-Mg@MSNs in different concentrations of CaCl2 and MgCl2 solutions were around 200 nm and negatively charged, and the PDI was more significant than 3%.

Nov 18, 2024 | mdpi.com | Farhan Shah |Mei Wang |Jianping Zhao |Joseph Lee

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Oct 27, 2024 | nature.com | Subbulakshmi Karthikeyan |Mei Wang |Patrick J. Casey

Cancer stem cells (CSCs) are a group of specially programmed tumor cells that possess the characteristics of perpetual cell renewal, increased invasiveness, and often, drug resistance. Hence, eliminating CSCs is a major challenge for cancer treatment. Understanding the cellular programs that maintain CSCs, and identifying the critical regulators for such programs, are major undertakings in both basic and translational cancer research. Recently, we have reported that RAB4A is a major regulator of epithelial-to-mesenchymal transition (EMT) and it does so mainly through regulating the activation of RAC1 GTPase. In the current study, we have delineated a new signaling circuitry through which RAB4A transmits its control of cancer stemness. Using in vitro and in vivo studies, we show that RAB4A, as the upstream regulator, relays signal stepwise to NUMB, NOTCH1, RAC1, and then SOX2 to control the self-renewal property of multiple cancer cells of diverse tissue origins. Knockdown of NUMB, or overexpression of NICD (the active fragment NOTCH1) or SOX2, rescued the in vitro sphere-forming and in vivo tumor-forming abilities that were lost upon RAB4A knockdown. Furthermore, we discovered that the chain of control is mostly through transcriptional regulation at every step of the pathway. The discovery of the novel signaling axis of RAB4A–NUMB–NOTCH–SOX2 opens the path for further expansion of the signaling chain and for the identification of new regulators and interacting proteins important for CSC functions, which can be explored to develop new and effective therapies.

Oct 20, 2024 | nature.com | Mei Wang

Electrochemical reduction of carbon dioxide to fuels and chemicals is usually mediated by metal-based catalysts. Now, a carbon electrode modified with an organic molecular catalyst demonstrates promising activity and selectivity for carbon dioxide electroreduction to methane via an unusual pathway.

Oct 9, 2024 | nature.com | Mengting Chen |Peijie Zhou |Suoqin Jin |Mei Wang |Qing Nie |Ben Wang | +1 more

AbstractRosacea is a chronic inflammatory skin disorder, whose underlying cellular and molecular mechanisms remain obscure. Here, we generate a single-cell atlas of facial skin from female rosacea patients and healthy individuals. Among keratinocytes, a subpopulation characterized by IFNγ-mediated barrier function damage is found to be unique to rosacea lesions. Blocking IFNγ signaling alleviates rosacea-like phenotypes and skin barrier damage in mice.