Peijie Zhou

Oct 9, 2024 | nature.com | Mengting Chen |Peijie Zhou |Suoqin Jin |Mei Wang |Qing Nie |Ben Wang | +1 more

AbstractRosacea is a chronic inflammatory skin disorder, whose underlying cellular and molecular mechanisms remain obscure. Here, we generate a single-cell atlas of facial skin from female rosacea patients and healthy individuals. Among keratinocytes, a subpopulation characterized by IFNγ-mediated barrier function damage is found to be unique to rosacea lesions. Blocking IFNγ signaling alleviates rosacea-like phenotypes and skin barrier damage in mice.

May 16, 2024 | nature.com | Peijie Zhou

AbstractSpatial transcriptomics and messenger RNA splicing encode extensive spatiotemporal information for cell states and transitions. The current lineage-inference methods either lack spatial dynamics for state transition or cannot capture different dynamics associated with multiple cell states and transition paths.