Michael H. Tatham

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Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation - Nature Structural & Molecular Biology

Apr 22, 2024 | nature.com | Ivo A. Hendriks |Michael H. Tatham |Gian-luca McLelland |Ronald T. Hay |Michael Nielsen |Thijn R. Brummelkamp | +1 more

AbstractProtein SUMOylation provides a principal driving force for cellular stress responses, including DNA–protein crosslink (DPC) repair and arsenic-induced PML body degradation. In this study, using genome-scale screens, we identified the human E3 ligase TOPORS as a key effector of SUMO-dependent DPC resolution.

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