Thijn R. Brummelkamp

May 29, 2024 | febs.onlinelibrary.wiley.com | Jitske Bak |Thijn R. Brummelkamp |Anastassis Perrakis

Abbreviations CAMSAP, calmodulin-regulated spectrin-associated protein CAP-Gly, cytoskeleton-associated protein glycine-rich CLIP, CAP-Gly domain containing linker protein cryo-EM, cryo electron microscopy EB, end-binding protein GTP, guanosine triphosphate HADDOCK, high ambiguity driven protein–protein docking HEK, human embryonic kidney IDR, intrinsically disordered region MAP, microtubule associated protein MARK, microtubule affinity regulating kinase MATCAP, microtubule-associated...

Apr 22, 2024 | nature.com | Ivo A. Hendriks |Michael H. Tatham |Gian-luca McLelland |Ronald T. Hay |Michael Nielsen |Thijn R. Brummelkamp | +1 more

AbstractProtein SUMOylation provides a principal driving force for cellular stress responses, including DNA–protein crosslink (DPC) repair and arsenic-induced PML body degradation. In this study, using genome-scale screens, we identified the human E3 ligase TOPORS as a key effector of SUMO-dependent DPC resolution.