Milica Radisic

Nov 14, 2024 | nature.com | Milica Radisic

Substrates with concave curvatures resembling those found in the developing embryo mechanically revert mouse and human pluripotent stem cells into a naivety-like state.

May 6, 2024 | nature.com | Homaira Hamidzada |Uros Kuzmanov |Renee Gorman |Michael Atkins |Babak Razani |Ana Andreazza | +2 more

AbstractYolk sac macrophages are the first to seed the developing heart; however, owing to a lack of accessible tissue, there is no understanding of their roles in human heart development and function. In this study, we bridge this gap by differentiating human embryonic stem (hES) cells into primitive LYVE1+ macrophages (hESC-macrophages) that stably engraft within contractile cardiac microtissues composed of hESC-cardiomyocytes and fibroblasts.

Nov 1, 2023 | nature.com | Milica Radisic

NEWS AND VIEWS 01 November 2023 An electrically conductive hydrogel injected into an injured muscle can help the muscle to regenerate and reconnect with the nervous system. This effective soft prosthesis has enabled rats to walk soon after muscular injury. When a muscle is injured, its electrical communication with the nervous system is disrupted, preventing it from functioning properly.

Aug 8, 2023 | aiche.onlinelibrary.wiley.com | Milica Radisic |Biomolecular Research

3.1 Recapitulating heart-SARS-CoV-2 interactions using heart-on-a-chip systems Heart-on-chip models integrating iPSC-derived cardiomyocyte and fibroblast cocultures have been utilized to generate contracting tissues and to simulate viral infection of cardiac tissue (Figure 6a). A number of reports using heart-on-a-chip models have shown that viral infection of cardiac tissues causes functional alterations. For instance, Marchiano et al.