Min Gao

Jan 11, 2025 | nature.com | Rui Ren |Xinyue Zhou |Tianyu Jia |Bin Wang |Min Gao |Liyan Wang | +6 more

Perfluorooctane sulfonate (PFOS) is a widely used chemical in industrial production. It can be introduced into the environment through multiple pathways and exhibits resistance to degradation. Recent research has demonstrated a significant correlation between its exposure levels in the human body and the incidence of various diseases. The expression of genes related to endometrial receptivity and the differentiation of human endometrial stromal cells (hESCs) were assessed in this study concerning PFOS. In this study, we investigated the effect of PFOS exposure on endometrial tolerance by cell and animal experiments. The activity against endometrial mesenchymal cells was significantly reduced by PFOS intervention, and the apoptosis flow assay results showed that PFOS significantly promoted cell death in a concentration-dependent manner. Transmission electron microscopy results revealed mitochondrial damage in the PFOS-intervened group, and WB results showed that the expression levels of endometrial tolerance-related proteins Homeobox A10 (HOXA10) and integrin beta3 (ITGB3) were decreased, and the expression level of Forkhead box O1 (FOXO1) protein was increased. Animal studies have shown that PFOS exposure can change uterine morphology, cause obvious damage to pinopodes morphology, change the estrous cycle of mice, and affect endometrial receptivity In the present study, we found that PFOS may synergistically affect the viability of endometrial mesenchymal stromal cells through accumulation in vivo, and that PFOS may contribute to the failure of embryo implantation by affecting mitochondrial function and consequently endometrial permissive sites.

Nov 7, 2024 | nature.com | Min Gao

AbstractBreast and gynecological cancers are common cancers with high mortality and have profound effects on the various physical functions of women. This study assessed trends in the number of hospitalizations, in-hospital mortality, length of stay (LOS), and hospital charges for female breast and gynecological cancer from 2004 to 2020. The data for this study come from the China Health Statistics Yearbook. Time trends of categorical variables were assessed with the Cochran-Armitage Test.

Jul 22, 2024 | preprints.org | Yuanyuan Sun |Min Gao |Yi Zhu

PreprintArticleVersion 1This version is not peer-reviewedVersion 1: Received: 19 July 2024 / Approved: 20 July 2024 / Online: 22 July 2024 (07:20:51 CEST)Sun, Y.; Gao, M.; Zhu, Y. The Presence of Selenium Nanoparticles May Enhance the Toxicity of Cadmium to Chlamydomonas reinhardtii – Evidence from Wild-Type and Cell-Deficient Chlamydomonas reinhardtii Cells. Preprints 2024, 2024071646. https://doi.org/10.20944/preprints202407.1646.v1Sun, Y.; Gao, M.; Zhu, Y.

Apr 12, 2024 | arxiv.org | Yufeng Li |Xu Yan |Min Gao |Weimin Wang

Apr 6, 2024 | mdpi.com | Yuan Gao |Guoliang Yu |Min Gao

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