Miner Deng

Sep 17, 2024 | onlinelibrary.wiley.com | Miner Deng |South Agricultural |Guangdong Laboratory |Zoonotic Diseases

1. Introduction Cholangitisis an important clinicalmanifestation of infections by many parasites, such as Cryptosporidium spp. in immunocompromised persons and liver trematodes (Opisthorchis spp., Clonorchis sinensis, and Fasciola hepatica) and cestodes (Echinococcus granulosus and E. multilocularis) in humans and animals in many parts of the world [1]. Despite its public and veterinary health significance, the pathogenesis of parasitic cholangitis is poorly understood.

Dec 6, 2023 | biorxiv.org | Tianyi Hou |Xinjie Mao |Jie Zhang |Miner Deng

AbstractCryptosporidium hominis and Cryptosporidium parvum are major causes of severe diarrhea in humans. Comparative studies of them are hampered by the lack of effective cultivation and cryopreservation methods, especially for C. hominis. Here, we described adapted murine enteroids for the cultivation of one C. parvum IId subtype and nonhuman primate-adapted C. hominis Ib, Im, and In subtypes, which allowed the complete development of the pathogens, producing oocysts infectious to mice.