Minghui Wang

Sep 14, 2024 | onlinelibrary.wiley.com | Minghui Wang |Wei Zhou |Yunlong Liu |Hongliu Yu

Background The artificial anal sphincter is a device used to treat patients with fecal incontinence who are unable to control their bowel movements on their own. Long-term morphological changes in the tissue surrounding the artificial anal sphincter can cause biomechanical compatibility problems, which seriously affect the clinical application of the artificial anal sphincter.

Mar 5, 2024 | biorxiv.org | Shouneng Peng |Erming Wang |Minghui Wang |Xusheng Wang

AbstractINTRODUCTION: The interconnection between brain aging and Alzheimer's disease (AD) remain to be elucidated. METHODS: We investigated multi-omics (transcriptomics and proteomics) data from multiple brain regions (i.e., the hippocampus (HIPP), prefrontal cortex (PFC), and cerebellum (CRBL)) in cognitively normal individuals. RESULTS: We found that brain samples could be divided into ADL (AD-like) and NL (normal) subtypes which were correlated across brain regions.

Apr 17, 2023 | dx.doi.org | Fangzheng Wu |JiaJun Liu |Menglin Tao |Minghui Wang

β-Galactosidase (β-gal) is the gold standard marker of cellular senescence, which is linked with various age-related diseases. Therefore, it is essential to develop more excellent probes that can real-time monitor β-gal activity in cellular senescence in vivo. Fluorescent/photoacoustic (FL/PA) dual-modal imaging possesses excellent sensitivity and spatial resolution.

Feb 22, 2023 | alz-journals.onlinelibrary.wiley.com | Minghui Wang |Lei Guo |John F. Fullard |Erming Wang

2.5 DMR-associated genes and AD risk genes After determining the methylomic contributions to gene and protein expression, we investigated correlations between individual DMRs and gene or protein expression. A gene was correlated with a DMR if it was significantly correlated with the DMR at a Benjamini–Hochberg (BH)-adjusted P-value < 0.05. We took the union of all the genes with significant positive correlations with a given DMR as the DMR-positively associated gene signature (PAS) for that DMR.