Erming Wang

Dec 5, 2024 | biorxiv.org | Abigail Thorpe |Qi Zeng |Erming Wang |Gefei Yu

AbstractAlzheimer's disease (AD) is the most common form of dementia, with approximately two-thirds of AD patients are females. Basic and clinical research studies show evidence supporting sex-specific differences contributing to the complexity of AD. There is also strong evidence supporting sex-specific interaction between the primary genetic risk factor of AD, APOE4 and AD-associated neurodegenerative processes.

Mar 5, 2024 | biorxiv.org | Shouneng Peng |Erming Wang |Minghui Wang |Xusheng Wang

AbstractINTRODUCTION: The interconnection between brain aging and Alzheimer's disease (AD) remain to be elucidated. METHODS: We investigated multi-omics (transcriptomics and proteomics) data from multiple brain regions (i.e., the hippocampus (HIPP), prefrontal cortex (PFC), and cerebellum (CRBL)) in cognitively normal individuals. RESULTS: We found that brain samples could be divided into ADL (AD-like) and NL (normal) subtypes which were correlated across brain regions.