Erming Wang

Dec 5, 2024 | biorxiv.org | Abigail Thorpe |Qi Zeng |Erming Wang |Gefei Yu

AbstractAlzheimer's disease (AD) is the most common form of dementia, with approximately two-thirds of AD patients are females. Basic and clinical research studies show evidence supporting sex-specific differences contributing to the complexity of AD. There is also strong evidence supporting sex-specific interaction between the primary genetic risk factor of AD, APOE4 and AD-associated neurodegenerative processes.

Mar 5, 2024 | biorxiv.org | Shouneng Peng |Erming Wang |Minghui Wang |Xusheng Wang

AbstractINTRODUCTION: The interconnection between brain aging and Alzheimer's disease (AD) remain to be elucidated. METHODS: We investigated multi-omics (transcriptomics and proteomics) data from multiple brain regions (i.e., the hippocampus (HIPP), prefrontal cortex (PFC), and cerebellum (CRBL)) in cognitively normal individuals. RESULTS: We found that brain samples could be divided into ADL (AD-like) and NL (normal) subtypes which were correlated across brain regions.

Feb 22, 2023 | alz-journals.onlinelibrary.wiley.com | Minghui Wang |Lei Guo |John F. Fullard |Erming Wang

2.5 DMR-associated genes and AD risk genes After determining the methylomic contributions to gene and protein expression, we investigated correlations between individual DMRs and gene or protein expression. A gene was correlated with a DMR if it was significantly correlated with the DMR at a Benjamini–Hochberg (BH)-adjusted P-value < 0.05. We took the union of all the genes with significant positive correlations with a given DMR as the DMR-positively associated gene signature (PAS) for that DMR.