Monica Kruk

Nov 3, 2024 | biorxiv.org | Abdur Rahim |Brian L. Ruis |Andrew Rajczewski |Monica Kruk

AbstractTen-Eleven Translocation (TET1-3) dioxygenases oxidize 5-methylcytosine (5mC) in DNA to generate 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC), initiating DNA demethylation. The three proteins share significant sequence homology and catalyze the same chemical reaction utilizing alpha-ketoglutarate cofactor and non-heme iron to oxidize the methyl group of 5mC.

Sep 10, 2024 | respiratory-research.biomedcentral.com | Sarah Samorodnitsky |Eric F Lock |Ken Kunisaki |Alison Morris |Janice M. Leung |Subina Mehta | +6 more

PLWH who had undergone bronchoscopy were selected from the Pittsburgh and Vancouver Lung HIV Cohorts [15, 16]. This consisted of individuals (n = 25) with OLD as defined as the ratio of forced expiratory volume in 1-s/forced vital capacity (FEV1/FVC) < lower limit of normal.