Naomi R. Wray

Apr 3, 2024 | nature.com | Jacob J. Crouse |Enda M. Byrne |Brittany Mitchell |Jan Scott |Sarah E. Medland |Naomi R. Wray | +1 more

AbstractThe dominant (‘general’) version of the diathesis-stress theory of depression views stressors and genetic vulnerability as independent risks. In the Australian Genetics of Depression Study (N = 14,146; 75% female), we tested whether polygenic scores (PGS) for major depression, bipolar disorder, schizophrenia, anxiety, ADHD, and neuroticism were associated with reported exposure to 32 childhood, past-year, lifetime, and accumulated stressful life events (SLEs).

Feb 26, 2024 | nature.com | Clara Albiñana |Zhihong Zhu |Nis Borbye-Lorenzen |Kristin Skogstrand |Naomi R. Wray |Joana A. Revez | +7 more

Correction to: Nature Communications https://doi.org/10.1038/s41467-023-36392-5, published online 15 February 2023The original version of this article contained an error in the second paragraph of the ‘Assay of DBP concentration’ section of the ‘Methods’, which incorrectly read ‘The lower and upper detection limits for DBP were 2.07 and 79.8 mg/L respectively’. The correct version states ‘2.07 µg/L’ in place of ‘2.07’. This has been corrected in both the PDF and HTML versions of the article.

Nov 1, 2023 | cell.com | Naomi R. Wray

Naomi Wray works at the interface of genetics, statistics and psychiatric disorders. With early training in quantitative genetics applied to livestock she brought to the field a perspective on the polygenic nature of common, complex disease. She advocates for experimental paradigms that exploit polygenicity to advance translational outcomes in psychiatry.

Feb 15, 2023 | nature.com | Clara Albiñana |Zhihong Zhu |Nis Borbye-Lorenzen |Kristin Skogstrand |Naomi R. Wray |Joana A. Revez | +7 more

AbstractThe vitamin D binding protein (DBP), encoded by the group-specific component (GC) gene, is a component of the vitamin D system. In a genome-wide association study of DBP concentration in 65,589 neonates we identify 26 independent loci, 17 of which are in or close to the GC gene, with fine-mapping identifying 2 missense variants on chromosomes 12 and 17 (within SH2B3 and GSDMA, respectively). When adjusted for GC haplotypes, we find 15 independent loci distributed over 10 chromosomes.