Sarah E. Medland

Oct 7, 2024 | nature.com | Julia Sidorenko |Kathryn E Kemper |Bjørn Olav Åsvold |Alireza Ani |Rujia Wang |Ilja M. Nolte | +13 more

AbstractLinkage studies have successfully mapped loci underlying monogenic disorders, but mostly failed when applied to common diseases. Conversely, genome-wide association studies (GWASs) have identified replicable associations between thousands of SNPs and complex traits, yet capture less than half of the total heritability.

Apr 3, 2024 | nature.com | Jacob J. Crouse |Enda M. Byrne |Brittany Mitchell |Jan Scott |Sarah E. Medland |Naomi R. Wray | +1 more

AbstractThe dominant (‘general’) version of the diathesis-stress theory of depression views stressors and genetic vulnerability as independent risks. In the Australian Genetics of Depression Study (N = 14,146; 75% female), we tested whether polygenic scores (PGS) for major depression, bipolar disorder, schizophrenia, anxiety, ADHD, and neuroticism were associated with reported exposure to 32 childhood, past-year, lifetime, and accumulated stressful life events (SLEs).

Mar 3, 2024 | nature.com | Michael Wainberg |Sarah E. Medland

AbstractMyelinated axons form long-range connections that enable rapid communication between distant brain regions, but how genetics governs the strength and organization of these connections remains unclear.

Oct 3, 2023 | onlinelibrary.wiley.com | Enda M. Byrne |Jan Scott |Jacob J. Crouse |Sarah E. Medland

CONFLICT OF INTEREST STATEMENT Sarah Medland is supported by an NHMRC SRF APP1103623. Jacob J. Crouse is supported by an NMHRC Emerging Leadership Fellowship (GNT2008197). Nicholas Martin and Jacob J. Crouse declare no conflict of interest. Jan Scott is a visiting professor at the Brain and Mind Centre and at Universite de Paris, the Norwegian University of Science and Technology (Trondheim) and is a ‘Science without Borders’ fellow (Brazil).