Brittany Mitchell

Oct 3, 2024 | mentalhealth.bmj.com | Enda M. Byrne |Mirim Shin |Jacob J. Crouse |Brittany Mitchell

DiscussionIn this study, we explored changes in sleep pattern during the COVID-19 pandemic in a genetically informative cohort of 6453 adults with a self-reported lifetime history of depression. This unique natural experiment unveiled significant shifts in sleep patterns. Despite increased flexibility to adjust their sleep schedules due to ‘lockdown’ regulations, the proportion of individuals with optimal sleep decreased, leading to transitions towards both short and long sleep patterns.

Jul 15, 2024 | medrxiv.org | Elise Koch |Tuuli Jürgenson |Gudmundur Einarsson |Brittany Mitchell

The authors have declared no competing interest. We would like to thank the research participants and employees of 23andMe, Inc. for making this work possible. This work was partly performed on the TSD (Tjeneste for Sensitive Data) facilities, owned by the University of Oslo, operated and developed by the TSD service group at the University of Oslo, IT-Department (USIT).

Apr 3, 2024 | nature.com | Jacob J. Crouse |Enda M. Byrne |Brittany Mitchell |Jan Scott |Sarah E. Medland |Naomi R. Wray | +1 more

AbstractThe dominant (‘general’) version of the diathesis-stress theory of depression views stressors and genetic vulnerability as independent risks. In the Australian Genetics of Depression Study (N = 14,146; 75% female), we tested whether polygenic scores (PGS) for major depression, bipolar disorder, schizophrenia, anxiety, ADHD, and neuroticism were associated with reported exposure to 32 childhood, past-year, lifetime, and accumulated stressful life events (SLEs).

Jan 5, 2024 | biologicalpsychiatryjournal.com | Enda M. Byrne |Byrne E.M |Jacob J. Crouse |Brittany Mitchell

Herrman H. Patel V. Kieling C. Berk M. Buchweitz C. Cuijpers P. et al. Time for united action on depression: a Lancet-World Psychiatric Association Commission. Lancet. 2022; 399: 957-1022Cipriani A. Furukawa T.A. Salanti G. Chaimani A. Atkinson L.Z. Ogawa Y. et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet.

Jan 4, 2024 | nature.com | Xiangrui Meng |Daniel F Levey |Dora Koller |Mark Adams |Miguel E. Rentería |Dan Stein | +42 more

AbstractMost genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to previously reported data. This analysis used a range of measures to define MD and included samples of African (36% of effective sample size), East Asian (26%) and South Asian (6%) ancestry and Hispanic/Latin American participants (32%).