Nikolaos P. Daskalakis

Dec 18, 2024 | genomemedicine.biomedcentral.com | Seyma Katrinli |Agaz Wani |Adam X. Maihofer |Andrew Ratanatharathorn |Nikolaos P. Daskalakis |Janitza L. Montalvo-Ortiz | +7 more

The study includes 2156 current PTSD cases and 2921 trauma-exposed controls from 9 civilian cohorts: BEAR, DNHS, DCHS, GTP, NIU, Shared Roots, AURORA, H3A_Rwanda, WTC; and 9 military cohorts: GMRFQUT, MRS, PRISMO, Army STARRS, PROGrESS, NCPTSD/TRACTS, INTRuST, and VA cohorts (VA-M-AA and VA-M-EA). For DNHS, GTP, MRS, PRISMO, and Army STARRS, two different datasets were available based on the DNAm array.

May 23, 2024 | science.org | W. Brad Ruzicka |Chengyu Deng |Cindy Wen |Nikolaos P. Daskalakis

Research ArticlePSYCHENCODE2Nikolaos P. Daskalakis [email protected], Artemis Iatrou, [...] , Chris Chatzinakos, Aarti Jajoo, [...] , Clara Snijders, Dennis Wylie, Christopher P. DiPietro, Ioulia Tsatsani, Chia-Yen Chen, [...] , Cameron D. Pernia, Marina Soliva-Estruch, Dhivya Arasappan, Rahul A. Bharadwaj, Leonardo Collado-Torres, Stefan Wuchty, Victor E. Alvarez, Eric B. Dammer, Amy Deep-Soboslay, Duc M. Duong, Nick Eagles, Bertrand R. Huber, Louise Huuki, Vincent L. Holstein, Mark W.

Oct 5, 2023 | nature.com | Nikolaos P. Daskalakis

Some individuals with post-traumatic stress disorder (PTSD) experience a series of symptoms attributable to ‘dissociation’ — severance either with themselves or their surroundings. A new study on the neurobiology of dissociation in PTSD uses functional MRI analysis to identify unique patterns of brain–behavior associations. After exposure to trauma, some individuals may develop post-traumatic stress disorder (PTSD).

Aug 14, 2023 | nature.com | Nikolaos P. Daskalakis

Brain genomic profiling, e.g., a bulk transcriptomic study on postmortem cortical tissue [2], uncovered global and sex-specific molecular signatures of PTSD including differentially expressed interneuron markers (ELFN1) and inflammation- and GC-related genes as key drivers of disease-associated networks (Fig. 1B) with moderate to low overlap with MDD. However, cell-type specificity in these analyses relied on inference, underlining the need for single-cell genomic approaches.

May 9, 2023 | nature.com | Poornima Kumar |Nikolaos P. Daskalakis |Kerry J. Ressler

AbstractThe pituitary adenylate cyclase-activating polypeptide (PACAP) system is implicated in posttraumatic stress disorder (PTSD) and related amygdala-mediated arousal and threat reactivity. PTSD is characterized by increased amygdala reactivity to threat and, more recently, aberrant intrinsic connectivity of the amygdala with large-scale resting state networks, specifically the default mode network (DMN).