Rüdiger Brühl

2 months ago | nature.com | Qingyang Li |Miao Cao |Dan Stein |Barbara Sahakian |Tianye Jia |Christelle Langley | +22 more

AbstractLaboratory studies show brain maturation involves synaptic pruning and cognitive development. Human studies suggest links between early cognitive performance and later mental health, but inconsistencies remain. It is unclear if specific brain regions mediate this relationship, and the molecular underpinnings are not well understood.

Jan 9, 2025 | nature.com | Xinyang Yu |Zuo Zhang |Moritz Herle |Tobias Banaschewski |Gareth Barker |Herta Flor | +16 more

AbstractUnhealthy eating, a risk factor for eating disorders (EDs) and obesity, often coexists with emotional and behavioral problems; however, the underlying neurobiological mechanisms are poorly understood. Analyzing data from the longitudinal IMAGEN adolescent cohort, we investigated associations between eating behaviors, genetic predispositions for high body mass index (BMI) using polygenic scores (PGSs), and trajectories (ages 14–23 years) of ED-related psychopathology and brain maturation.

Jul 14, 2024 | nature.com | Runye Shi |Shitong Xiang |Tianye Jia |Trevor Robbins |Jujiao Kang |Tobias Banaschewski | +21 more

AbstractAdolescents exhibit remarkable heterogeneity in the structural architecture of brain development. However, due to limited large-scale longitudinal neuroimaging studies, existing research has largely focused on population averages, and the neurobiological basis underlying individual heterogeneity remains poorly understood.

Jul 1, 2024 | nature.com | Tobias Banaschewski |Sylvane Desrivières |Herta Flor |Penny Gowland |Andreas Heinz |Rüdiger Brühl | +9 more

AbstractPerseverative negative thoughts, known as rumination, might arise from emotional challenges and preclude mental health when transitioning into adulthood. Due to its multifaceted nature, rumination can take several ruminative response styles, that diverge in manifestations, severity, and mental health outcomes. Still, prospective ruminative phenotypes remain elusive insofar.

Oct 19, 2023 | nature.com | Tobias Banaschewski |Gareth Barker |Sylvane Desrivières |Herta Flor |Penny Gowland |Andreas Heinz | +17 more

AbstractThe cerebral ventricles are recognized as windows into brain development and disease, yet their genetic architectures, underlying neural mechanisms and utility in maintaining brain health remain elusive. Here we aggregated genetic and neuroimaging data from 61,974 participants (age range, 9 to 98 years) in five cohorts to elucidate the genetic basis of ventricular morphology and examined their overlap with neuropsychiatric traits.