Oliver Fiehn

Oct 25, 2024 | mdpi.com | Oliver Fiehn

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Feb 28, 2024 | biorxiv.org | Aditi Bhargava |Johannes Knapp |Oliver Fiehn

AbstractPosttraumatic stress disorder (PTSD) is widely recognized as a common consequence of trauma exposure. Women are at particularly high risk, with some studies finding that women develop PTSD at twice the rate of men, despite greater trauma exposure in men. Lipids and their metabolites (lipidome) regulate a myriad of key biological processes and pathways such as membrane integrity, oxidative stress, and neuroinflammation in the brain by maintaining neuronal connectivity and homeostasis.

Sep 21, 2023 | nature.com | Yuanyue Li |Oliver Fiehn

AbstractPublic repositories of metabolomics mass spectra encompass more than 1 billion entries. With open search, dot product or entropy similarity, comparisons of a single tandem mass spectrometry spectrum take more than 8 h. Flash entropy search speeds up calculations more than 10,000 times to query 1 billion spectra in less than 2 s, without loss in accuracy. It benefits from using multiple threads and GPU calculations.

May 10, 2023 | nature.com | Dari Shalon |Rebecca Neal Culver |Jessica A. Grembi |Handuo Shi |Florian A. Rosenberger |Sean P Spencer | +5 more

AbstractThe spatiotemporal structure of the human microbiome1,2, proteome3 and metabolome4,5 reflects and determines regional intestinal physiology and may have implications for disease6. Yet, little is known about the distribution of microorganisms, their environment and their biochemical activity in the gut because of reliance on stool samples and limited access to only some regions of the gut using endoscopy in fasting or sedated individuals7.