Olivier Elemento

2 months ago | cell.com | Rocio Vicario |Stamatina Fragkogianni |Maria Pokrovskii |Carina Meyer |Estibaliz Lopez-Rodrigo |Yang Hu | +31 more

Keywords Neurodegeneration MAPK pathway microglia hippocampus brainstem resident macrophages Introduction Langerhans cell histiocytosis (LCH)1 and Erdheim-Chester disease (ECD)2,3 are rare clonal myeloid disorders, with an estimated incidence of ∼5 cases per million people per year.4 They are sometimes co-diagnosed in the same patients,5 and both associated with a high prevalence of the BRAFV600E mutation1,2,3,6,7,8 as well as an increased risk of neurodegenerative disease...

Nov 21, 2024 | nature.com | Mehran Karimzadeh |Helen Li |Olivier Elemento |James Zou |Fereydoun Hormozdiari |Babak Alipanahi

AbstractLiquid biopsies have the potential to revolutionize cancer care through non-invasive early detection of tumors. Developing a robust liquid biopsy test requires collecting high-dimensional data from a large number of blood samples across heterogeneous groups of patients. We propose that the generative capability of variational auto-encoders enables learning a robust and generalizable signature of blood-based biomarkers.

Sep 29, 2024 | onlinelibrary.wiley.com | Jacob L. Glass |Olivier Elemento

CONFLICT OF INTEREST STATEMENT JLG has consulted for the Gerson Lehrman Group. REFERENCES 1, , , , , , et al. Attention is all you need. 2017. arXiv:1706.03762. https://doi.org/10.48550/arXiv.1706.03762 2, , , , , , et al. A survey on evaluation of large language models. ACM Trans Intell Syst Technol. 2024; 15(3): 1–45. 3, , , , , , et al. Llama 2: open foundation and fine-tuned chat models. 2023. arXiv:2307.09288. https://doi.org/10.48550/arXiv.2307.09288 4, , , , , , et al.

Jul 30, 2024 | nature.com | Giorgio G. Inghirami |Olivier Elemento

Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma, and over 60% patients can achieve durable remission after receiving standard immunotherapy treatment that comprises rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) [1,2,3]. The remaining patients are refractory to this frontline treatment or suffer tumor relapses with an extremely poor prognosis [4].

Jun 28, 2024 | nature.com | Linda Bojmar |Constantinos P. Zambirinis |Junbum Kim |Ankur Choubey |Jose Jessurun |Hakon Blomstrand | +21 more

AbstractMetastasis occurs frequently after resection of pancreatic cancer (PaC). In this study, we hypothesized that multi-parametric analysis of pre-metastatic liver biopsies would classify patients according to their metastatic risk, timing and organ site.