Olivier Elemento

Nov 21, 2024 | nature.com | Mehran Karimzadeh |Helen Li |Olivier Elemento |James Zou |Fereydoun Hormozdiari |Babak Alipanahi

AbstractLiquid biopsies have the potential to revolutionize cancer care through non-invasive early detection of tumors. Developing a robust liquid biopsy test requires collecting high-dimensional data from a large number of blood samples across heterogeneous groups of patients. We propose that the generative capability of variational auto-encoders enables learning a robust and generalizable signature of blood-based biomarkers.

Sep 29, 2024 | onlinelibrary.wiley.com | Jacob L. Glass |Olivier Elemento

CONFLICT OF INTEREST STATEMENT JLG has consulted for the Gerson Lehrman Group. REFERENCES 1, , , , , , et al. Attention is all you need. 2017. arXiv:1706.03762. https://doi.org/10.48550/arXiv.1706.03762 2, , , , , , et al. A survey on evaluation of large language models. ACM Trans Intell Syst Technol. 2024; 15(3): 1–45. 3, , , , , , et al. Llama 2: open foundation and fine-tuned chat models. 2023. arXiv:2307.09288. https://doi.org/10.48550/arXiv.2307.09288 4, , , , , , et al.

Jul 30, 2024 | nature.com | Giorgio G. Inghirami |Olivier Elemento

Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma, and over 60% patients can achieve durable remission after receiving standard immunotherapy treatment that comprises rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) [1,2,3]. The remaining patients are refractory to this frontline treatment or suffer tumor relapses with an extremely poor prognosis [4].

Jun 28, 2024 | nature.com | Linda Bojmar |Constantinos P. Zambirinis |Junbum Kim |Ankur Choubey |Jose Jessurun |Hakon Blomstrand | +21 more

AbstractMetastasis occurs frequently after resection of pancreatic cancer (PaC). In this study, we hypothesized that multi-parametric analysis of pre-metastatic liver biopsies would classify patients according to their metastatic risk, timing and organ site.

Mar 17, 2024 | nature.com | André Figueiredo Rendeiro |Hiranmayi Ravichandran |Aram Vosoughi |Shaham Beg |David Wilkes |Brian Robinson | +5 more

AbstractThe molecular characteristics of metastatic upper tract urothelial carcinoma (UTUC) are not well understood, and there is a lack of knowledge regarding the genomic and transcriptomic differences between primary and metastatic UTUC. To address these gaps, we integrate whole-exome sequencing, RNA sequencing, and Imaging Mass Cytometry using lanthanide metal-conjugated antibodies of 44 tumor samples from 28 patients with high-grade primary and metastatic UTUC.