Pavel Kolkhir

3 weeks ago | healio.com | Richard Gawel |Kristen Dowd |Thomas Casale |Pavel Kolkhir

Read more Key takeaways: Higher mortality rates persisted across stratifications based on comorbidities, sex, age, race and treatment. Patients with chronic spontaneous urticaria were three times more likely to die by suicide. Adults with chronic spontaneous urticaria experienced greater mortality, probably due to increased risks for comorbidities, compared with a control group, according to a study published in The Journal of Allergy and Clinical Immunology.

Sep 26, 2024 | jamanetwork.com | Pavel Kolkhir |Humboldt-Universität zu Berlin |Pharmacology ITMP |Hanna Bonnekoh

Abstract Importance  Chronic spontaneous urticaria affects approximately 1% of the general population worldwide, including approximately 3 million people in the US, impairs patients’ quality of life, and is associated with multiple comorbidities. Observations  Chronic spontaneous urticaria affects patients of any age but is most common in females aged 30 to 50 years. Diagnosis is based on clinical presentation, ie, spontaneously recurring wheals, angioedema, or both.

Aug 1, 2023 | nature.com | Pavel Kolkhir |Thomas Bieber |Emma Guttman-Yassky |Martin Metz |Harald Renz

AbstractOver the past two decades, significant progress in understanding of the pathogenesis of type 2 chronic inflammatory diseases has enabled the identification of compounds for more than 20 novel targets, which are approved or at various stages of development, finally facilitating a more targeted approach for the treatment of these disorders.

Feb 9, 2023 | nature.com | Pavel Kolkhir |Marcus Maurer |Brecht Devleesschauwer

A rare disease is any type of disease that affects only a small proportion of the population. As of now, there is no consensus on an international definition of rare diseases1. In the European Union, a rare disease is defined as one affecting <5 per 10,000 people, whereas in the United States a disease is considered rare if it affects fewer than 200,000 people nationally.