Pharmacology ITMP

Sep 26, 2024 | jamanetwork.com | Pavel Kolkhir |Humboldt-Universität zu Berlin |Pharmacology ITMP |Hanna Bonnekoh

Abstract Importance  Chronic spontaneous urticaria affects approximately 1% of the general population worldwide, including approximately 3 million people in the US, impairs patients’ quality of life, and is associated with multiple comorbidities. Observations  Chronic spontaneous urticaria affects patients of any age but is most common in females aged 30 to 50 years. Diagnosis is based on clinical presentation, ie, spontaneously recurring wheals, angioedema, or both.

Aug 7, 2024 | onlinelibrary.wiley.com | Joachim W Fluhr |Pharmacology ITMP |Peter Menzel |Rolf Schwarzer

INTRODUCTION The barrier protective function predominantly resides in the stratum corneum (SC) of the epidermis and accomplishes an effective barrier towards the uncontrolled loss of water and the penetration of potentially harmful exogenous substances through the skin [1-3]. The SC, the outermost layer of the epidermis, comprises a lipid matrix primarily composed of ceramides, cholesterol and free fatty acids [1, 4-6].

Mar 13, 2024 | academic.oup.com | Pharmacology ITMP

In the recent mpox outbreak, people living with HIV (PLWH) were at high risk both for contracting infection and for suffering a more severe disease course. We studied cellular and humoral immune responses elicited by mpox infection (n = 5; n = 3 PLWH) or smallpox vaccination (n = 17; all PLWH) in a cohort of men who have sex with men. All PLWH were successfully treated, with stable CD4 counts and undetectable HIV viral loads. 11/17 vaccinated individuals had received childhood smallpox vaccination.

Feb 24, 2024 | academic.oup.com | Pharmacology ITMP |Technische Universität Dresden

Clinical assessment of an individual's sense of smell has gained prominence, but its resource-intensive nature necessitates the exploration of self-administered methods. In this study, a cohort of 68 patients with olfactory loss and 55 controls were assessed using a recently introduced olfactory test. This test involves sorting two odorants (eugenol, phenylethyl alcohol) in five dilutions according to odor intensity, with an average application time of 3.5 minutes.

Nov 21, 2023 | link.springer.com | Humboldt-Universität zu Berlin |Pharmacology ITMP |Quebec City |Universitat Pompeu Fabra

AbstractChronic urticaria (CU) is the recurring development of wheals (aka “hives” or “welts”), angioedema, or both for more than 6 weeks. Wheals and angioedema occur with no definite triggers in chronic spontaneous urticaria, and in response to known and definite physical triggers in chronic inducible urticaria. Approximately 1.4% of individuals globally will have CU during their lifetime.