Pedro R. Cutillas

Nov 13, 2024 | nature.com | Adam Oxley |Pedro R. Cutillas

AbstractPEGylation (the covalent attachment of one or more poly(ethylene glycol) (PEG) units to a therapeutic) is a well-established technique in the pharmaceutical industry to increase blood-residence time and decrease immunogenicity. A challenging aspect of PEGylation is the dispersity of PEGylation agents, which results in batch-to-batch variations and analytical limitations.

Aug 20, 2024 | nature.com | Sarah E. Conduit |Laura Bozal-Basterra |Mathias Cobbaut |Sandra D Castillo |Arkaitz Carracedo |Mariona Graupera | +5 more

AbstractPrimary cilia are antenna-like organelles which sense extracellular cues and act as signalling hubs. Cilia dysfunction causes a heterogeneous group of disorders known as ciliopathy syndromes affecting most organs. Cilia disassembly, the process by which cells lose their cilium, is poorly understood but frequently observed in disease and upon cell transformation. Here, we uncover a role for the PI3Kα signalling enzyme in cilia disassembly.