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1 month ago | 
nature.com | Pedro Ramos-Cabrer |Alberto Cabrera-Zubizarreta |Daniel Padro |Mario Matute-Gonzalez |Alfredo Rodríguez-Antigüedad |Carlos Matute
Here we use magnetic resonance imaging to study the impact of marathon running on brain structure in humans. We show that the signal for myelin water fraction—a surrogate of myelin content—is substantially reduced upon marathon running in specific brain regions involved in motor coordination and sensory and emotional integration, but recovers within two months. These findings suggest that brain myelin content is temporarily and reversibly diminished by severe exercise, a finding consistent with recent evidence from rodent studies that suggest that myelin lipids may act as glial energy reserves in extreme metabolic conditions. Using magnetic resonance imaging on marathon runners, Ramos-Cabrer, Cabrera-Zubizarreta et al. report that the signal detected as a surrogate of myelin content is significantly reduced after exercise, but fully recovered within two months.
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May 23, 2024 | 
nature.com | Daniel Jimenez-Blasco |Jesús Agulla |Rebeca Lapresa |Marina Garcia-Macia |Darío García-Rodríguez |Yannick Jeanson | +4 more
AbstractThe energy cost of neuronal activity is mainly sustained by glucose1,2. However, in an apparent paradox, neurons modestly metabolize glucose through glycolysis3,4,5,6, a circumstance that can be accounted for by the constant degradation of 6-phosphofructo-2-kinase–fructose-2,6-bisphosphatase-3 (PFKFB3)3,7,8, a key glycolysis-promoting enzyme.
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Mar 10, 2024 | 
biorxiv.org | Daniel Soler |Mohamed Selim |Emma Muñoz-Moreno |Pedro Ramos-Cabrer
AbstractBrain extraction, i.e. the precise removal of MRI signal outside the brain boundaries, is a key step in MRI preprocessing pipelines, typically achieved via masks delineating the region of interest (ROI). Existing automated tools often lack accuracy for rodent MRI due to resolution limitations, so large manual editing efforts are required. This work introduces SAMson, a high-precision automated mask generator built on Meta AI′s Segment-Anything Model (SAM).
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Feb 2, 2024 | 
culturacientifica.com | César Tomé |Pedro Ramos-Cabrer |Alberto Cabrera-Zubizarreta |Daniel Padro
Un equipo de investigación ha examinado el efecto de correr un maratón sobre la mielina, la sustancia que envuelve los axones de las neuronas, las prolongaciones en forma de hilo por las que se transmiten los impulsos nerviosos. Los resultados muestran que la mielina sufre una fuerte disminución generalizada y se recupera de manera progresiva posteriormente. Este hallazgo revela que el metabolismo energético cerebral es más complejo de lo que se pensaba.
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Jan 25, 2024 | 
ehu.eus | Pedro Ramos-Cabrer |Alberto Cabrera-Zubizarreta |Daniel Padro |Mario Matute-Gonzalez
La comunicación cerebral se rige por señales eléctricas y químicas que requieren mucha energía. Se estima que el cerebro consume el 20 % de la energía total que gasta el cuerpo humano, a pesar de que representa en torno al 2 % de su peso, y su principal fuente de energía es la glucosa.
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Jan 15, 2024 | 
nature.com | Cristina Simó |Ana C. Hortelao |Valerio Di Carlo |Sandra Guallar-Garrido |Pedro Ramos-Cabrer |Vanessa Gómez-Vallejo | +6 more
AbstractBladder cancer treatment via intravesical drug administration achieves reasonable survival rates but suffers from low therapeutic efficacy. To address the latter, self-propelled nanoparticles or nanobots have been proposed, taking advantage of their enhanced diffusion and mixing capabilities in urine when compared with conventional drugs or passive nanoparticles. However, the translational capabilities of nanobots in treating bladder cancer are underexplored.
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Oct 10, 2023 | 
biorxiv.org | Pedro Ramos-Cabrer |Alberto Cabrera-Zubizarreta |Daniel Padro |Mario Matute-Gonzalez
AbstractRecent evidence suggests that myelin lipids may act as glial energy reserves when glucose is lacking, a hypothesis yet to be solidly proven. Hereby, we examined the effects of running a marathon on the myelin content by MRI. Our findings show that marathon runners undergo widespread robust myelin decrease at completion of the effort.
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Aug 10, 2023 | 
frontiersin.org | Pedro Ramos-Cabrer |Jun-Jie Zhang |Nicoletta Marchesi
1. Introduction
Acute ischemic stroke (AIS), one of the leading causes of disability and death worldwide (1, 2), is characterized by high incidence, high recurrence, and high mortality. Hypertension is regarded as a primary risk factor for AIS (1, 3), and most hypertensive patients are accompanied by an increase in serum homocysteine (Hcy) (4, 5), which is defined as H-type hypertension (HHTN), which means a combination of essential hypertension and a high level of Hcy (6).
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Jun 5, 2023 | 
frontiersin.org | Pedro Ramos-Cabrer |Özlem Başıböyük Coşkun |Yan-Feng Wu |Shikun Cai
1. Introduction
Stroke is caused by cerebral vascular occlusion or hemorrhage. Among all cerebral strokes, acute ischemic stroke (AIS) has the highest incidence (~87%). Currently, AIS is the leading cause of disability and the second most common cause of death worldwide. In the United States, a new stroke occurs every 40 s on average (1).
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May 23, 2023 | 
mdpi.com | Pedro Ramos-Cabrer |Jesús Ruiz-Cabello
Open AccessEditorialbyPedro Ramos-Cabrer 1,2,* and Jesús Ruiz-Cabello 1,2,3,4,* 1CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), 20014 San Sebastian, Spain2Ikerbasque, Basque Foundation for Science, 48009 Bilbao, Spain3Biomedical Research Networking Center in Respiratory Diseases (CIBERES), 28029 Madrid, Spain4Department of Chemistry in Pharmaceutical Sciences, Pharmacy School, University Complutense Madrid, 28040 Madrid, Spain*Authors to whom correspondence should be addressed.
