Philip K. McGuire

Jan 21, 2025 | nature.com | Maite Arribas |Rashmi Patel |Robert McCutcheon |Daniel Stahl |Philip K. McGuire |Paolo Fusar-Poli

AbstractModelling the prodrome to severe mental disorders (SMD), including unipolar mood disorders (UMD), bipolar mood disorders (BMD) and psychotic disorders (PSY), should consider both the evolution and interactions of symptoms and substance use (prodromal features) over time.

Jan 18, 2024 | nature.com | Cathy Davies |Daniel Martins |Ottavia Dipasquale |Dominic Oliver |Steve Williams |Philip K. McGuire | +1 more

AbstractAbnormalities in functional brain networks (functional connectome) are increasingly implicated in people at Clinical High Risk for Psychosis (CHR-P). Intranasal oxytocin, a potential novel treatment for the CHR-P state, modulates network topology in healthy individuals. However, its connectomic effects in people at CHR-P remain unknown.

Jan 7, 2024 | nature.com | Ana Catalán |Robert McCutcheon |Marco Solmi |Philip K. McGuire |William Stone |Robin Murray

AbstractNeurocognitive deficits are a core feature of psychotic disorders, but it is unclear whether they affect all individuals uniformly. The aim of this systematic review and meta-analysis was to synthesize the evidence on the magnitude, progression, and variability of neurocognitive functioning in individuals with first-episode psychosis (FEP). A multistep literature search was conducted in several databases up to November 1, 2022.

Nov 15, 2023 | jamanetwork.com | Graham Blackman |Matthew J Kempton |Philip K. McGuire

Concerns Regarding Strength of Conclusions in Systematic Review and Meta-Analysis of Neuroradiological Abnormalities in First-Episode Psychosis—Reply In Reply We agree with Forbes et al that one of the key reasons for magnetic resonance imaging (MRI) scanning in people with first-episode psychosis (FEP) is to exclude an organic cause. However, we do not agree that radiologic findings are only clinically significant if they are causal.

Jul 12, 2023 | inkl.com | Graham Blackman |Philip K. McGuire

The study – which has been published in the JAMA Psychiatry journal – said “failure to detect such cases” in their early stages “can have serious clinical consequences”, and it has been suggested that MRIs should be “mandatory” for all FEP patients. However, it added it “remains a controversial issue, partly because the prevalence of clinically relevant MRI abnormalities in this group is unclear”.