Robert McCutcheon

Jan 21, 2025 | nature.com | Maite Arribas |Rashmi Patel |Robert McCutcheon |Daniel Stahl |Philip K. McGuire |Paolo Fusar-Poli

AbstractModelling the prodrome to severe mental disorders (SMD), including unipolar mood disorders (UMD), bipolar mood disorders (BMD) and psychotic disorders (PSY), should consider both the evolution and interactions of symptoms and substance use (prodromal features) over time.

Oct 3, 2024 | cambridge.org | Emilio Fernandez-Egea |Robert McCutcheon

In this issue, Oloyede and colleaguesReference Oloyede, Bachmann, Dzahini, Lopez Alcaraz, Singh and Vallianatu1 advocate for updating the haematological requirements for clozapine to increase access to this important drug. Their research indicates that the current system overestimates the incidence of clozapine-induced agranulocytosis (CIA), adding to the growing body of evidence suggesting a lack of significant CIA risk in the medium and long term.

May 8, 2024 | psiquiatria.com | Robert McCutcheon |David Taylor

Se recomiendan antipsicóticos para la prevención de recaídas en la esquizofrenia. No está claro si el mayor riesgo de recaída después de la interrupción del antipsicótico se asocia predominantemente con una magnitud absoluta de reducción de la dosis o la tasa de reducción del antipsicótico. Es importante establecer el mecanismo responsable porque se ha sugerido que los esquemas de abstinencia prolongados reducen el riesgo de recaída.

Feb 2, 2024 | biologicalpsychiatryjournal.com | Kate Merritt |Robert McCutcheon |Sarah Ashley |Anthony David

Glutamatergic dysfunction is implicated in schizophrenia pathoaetiology, but this may vary in extent between patients. We examine whether patients exhibit greater variability in glutamate measures compared to controls and conduct an updated meta-analysis of glutamate differences.

Jan 7, 2024 | nature.com | Ana Catalán |Robert McCutcheon |Marco Solmi |Philip K. McGuire |William Stone |Robin Murray

AbstractNeurocognitive deficits are a core feature of psychotic disorders, but it is unclear whether they affect all individuals uniformly. The aim of this systematic review and meta-analysis was to synthesize the evidence on the magnitude, progression, and variability of neurocognitive functioning in individuals with first-episode psychosis (FEP). A multistep literature search was conducted in several databases up to November 1, 2022.