Robin Murray

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Articles

The effect of polygenic risk score and childhood adversity on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis | Translational Psychiatry

Oct 25, 2024 | nature.com | Luis Alameda |Marta Di Forti |Celso Arango |Miguel Bernardo |Julio Bobes |Cristina Marta Del-Ben | +11 more

AbstractChildhood adversity is associated with various clinical dimensions in psychosis; however, how genetic vulnerability shapes the adversity-associated psychopathological signature is yet to be studied.
Should recreational cannabis be legalised in the UK?

Oct 16, 2024 | bmj.com | David Nutt |Lucy Stafford |Robin Murray |Laura Stack

Intended for healthcare professionals News & ViewsShould recreational... Should recreational cannabis be legalised in the UK?
Methylomic signature of current cannabis use in two first-episode psychosis cohorts - Molecular Psychiatry

Oct 15, 2024 | nature.com | Emma Dempster |Eilis Hannon |Diego Quattrone |Edoardo Spinazzola |Zhikun Li |Charlotte Gayer-Anderson | +17 more

AbstractThe rising prevalence and legalisation of cannabis worldwide have underscored the need for a comprehensive understanding of its biological impact, particularly on mental health. Epigenetic mechanisms, specifically DNA methylation, have gained increasing recognition as vital factors in the interplay between risk factors and mental health.
Systematic review and meta-analysis on the effects of chronic peri-adolescent cannabinoid exposure on schizophrenia-like behaviour in rodents - Molecular Psychiatry

Aug 1, 2024 | nature.com | Zhikun Li |Diptendu Mukherjee |Bea Duric |Diego Quattrone |Robin Murray |Edoardo Spinazzola

AbstractThe link between cannabis use and schizophrenia is well-established in epidemiological studies, especially among adolescents with early-onset use. However, this association in rodent models is less clear. This meta-analysis examined the effects of adolescent cannabinoid exposure on distinct schizophrenia-like behaviours in rodents and how experimental variations influence outcomes.
Diminished social motivation in early psychosis is associated with polygenic liability for low vitamin D - Translational Psychiatry

Jan 17, 2024 | nature.com | Sarah Tosato |Pentagiotissa Stefanatou |Robin Murray |Evangelos Vassos |Alex Hatzimanolis |Rigas-Filippos Soldatos

AbstractInsufficiency of vitamin D levels often occur in individuals with schizophrenia and first-episode psychosis (FEP). However, it is unknown whether this represents a biological predisposition, or it is essentially driven by illness-related alterations in lifestyle habits. Lower vitamin D has also been associated with adverse neurodevelopmental outcomes and predominant negative psychotic symptoms.
The magnitude and variability of neurocognitive performance in first-episode psychosis: a systematic review and meta-analysis of longitudinal studies - Translational Psychiatry

Jan 7, 2024 | nature.com | Ana Catalán |Robert McCutcheon |Marco Solmi |Philip K. McGuire |William Stone |Robin Murray

AbstractNeurocognitive deficits are a core feature of psychotic disorders, but it is unclear whether they affect all individuals uniformly. The aim of this systematic review and meta-analysis was to synthesize the evidence on the magnitude, progression, and variability of neurocognitive functioning in individuals with first-episode psychosis (FEP). A multistep literature search was conducted in several databases up to November 1, 2022.
Extreme deviations from the normative model reveal cortical heterogeneity and associations with negative symptom severity in first-episode psychosis from the OPTiMiSE and GAP studies | Translational Psychiatry

Dec 1, 2023 | nature.com | Celso Arango |Richard Dinga |Birte Glenthøj |René S. Kahn |Robin Murray |Carmine Pariante | +2 more

AbstractThere is currently no quantifiable method to predict long-term clinical outcomes in patients presenting with a first episode of psychosis. A major barrier to developing useful markers for this is biological heterogeneity, where many different pathological mechanisms may underly the same set of symptoms in different individuals.
Psychosis brain subtypes validated in first-episode cohorts and related to illness remission: results from the PHENOM consortium - Molecular Psychiatry

May 5, 2023 | nature.com | Dominic B. Dwyer |Alessandro Pigoni |Junhao Wen |Gyujoon Hwang |Guray Erus |René S. Kahn | +11 more

AbstractUsing machine learning, we recently decomposed the neuroanatomical heterogeneity of established schizophrenia to discover two volumetric subgroups—a ‘lower brain volume’ subgroup (SG1) and an ‘higher striatal volume’ subgroup (SG2) with otherwise normal brain structure.
Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis-findings from the EU-GEI study | Molecular Psychiatry

Apr 16, 2023 | nature.com | Luis Alameda |Zhonghua Liu |Celso Arango |Miguel Bernardo |Julio Bobes |Peter Jones | +14 more

AbtractStudies conducted in psychotic disorders have shown that DNA-methylation (DNAm) is sensitive to the impact of Childhood Adversity (CA). However, whether it mediates the association between CA and psychosis is yet to be explored. Epigenome wide association studies (EWAS) using the Illumina Infinium-Methylation EPIC array in peripheral blood tissue from 366 First-episode of psychosis and 517 healthy controls was performed.

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