Preben mortensen

Nov 29, 2023 | nature.com | Clare Palmer |Morten Krebs |Vivek Appadurai |Esben Agerbo |Anders D. Børglum |David M. Hougaard | +7 more

AbstractAttention deficit hyperactivity disorder (ADHD) is a complex disorder that manifests variability in long-term outcomes and clinical presentations. The genetic contributions to such heterogeneity are not well understood. Here we show several genetic links to clinical heterogeneity in ADHD in a case-only study of 14,084 diagnosed individuals. First, we identify one genome-wide significant locus by comparing cases with ADHD and autism spectrum disorder (ASD) to cases with ADHD but not ASD.

Nov 12, 2023 | nature.com | Clara Albiñana |Bjarni J Vilhjálmsson |Thomas Werge |David M. Hougaard |Anders D. Børglum |Preben mortensen | +1 more

AbstractIt remains inconclusive whether postpartum depression (PPD) and depression with onset outside the postpartum period (MDD) are genetically distinct disorders. We aimed to investigate whether polygenic risk scores (PGSs) for major mental disorders differ between PPD cases and MDD cases in a nested case-control study of 50,057 women born from 1981 to 1997 in the iPSYCH2015 sample in Demark.

Aug 5, 2023 | nature.com | Clara Albiñana |Hugues Aschard |Cynthia Bulik |Jakob Grove |David M. Hougaard |Thomas Werge | +5 more

AbstractThe predictive performance of polygenic scores (PGS) is largely dependent on the number of samples available to train the PGS. Increasing the sample size for a specific phenotype is expensive and takes time, but this sample size can be effectively increased by using genetically correlated phenotypes. We propose a framework to generate multi-PGS from thousands of publicly available genome-wide association studies (GWAS) with no need to individually select the most relevant ones.