Qin Luo

Nov 6, 2024 | digitalcommons.library.tmc.edu | Xiangdong Lv |Xuan Lu |Jin Cao |Qin Luo

AbstractDespite substantial advances in targeting mutant KRAS, tumor resistance to KRAS inhibitors (KRASi) remains a major barrier to progress. Here, we report proteostasis reprogramming as a key convergence point of multiple KRASi-resistance mechanisms. Inactivation of oncogenic KRAS down-regulated both the heat shock response and the inositol-requiring enzyme 1α (IRE1α) branch of the unfolded protein response, causing severe proteostasis disturbances.

Aug 25, 2023 | dx.doi.org | Binbin Wang |Qin Luo |Yujia Pan |Zihan Mei

Download Hi-Res ImageDownload to MS-PowerPointCite This:Environ. Sci. Technol. 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).

Jul 11, 2023 | mdpi.com | Huawei Li |Qin Luo |Huiyuan Jing |Yuzhen Song

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