Xuan Lu

Nov 6, 2024 | digitalcommons.library.tmc.edu | Xiangdong Lv |Xuan Lu |Jin Cao |Qin Luo

AbstractDespite substantial advances in targeting mutant KRAS, tumor resistance to KRAS inhibitors (KRASi) remains a major barrier to progress. Here, we report proteostasis reprogramming as a key convergence point of multiple KRASi-resistance mechanisms. Inactivation of oncogenic KRAS down-regulated both the heat shock response and the inositol-requiring enzyme 1α (IRE1α) branch of the unfolded protein response, causing severe proteostasis disturbances.

Jun 5, 2024 | onlinelibrary.wiley.com | Ning Zhao |Limin Liu |Xuan Lu |Yuyang Li

Conflict of interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.

Sep 8, 2023 | sciencemag.org | Xiangdong Lv |Moritz Peiseler |Guojun He |Xuan Lu

Published In ScienceVolume 381 | Issue 66628 September 2023Article versionsSubmission historyReceived: 24 November 2021Accepted: 28 July 2023Published in print: 8 September 2023PermissionsRequest permissions for this article. AcknowledgmentsWe thank J. Rosen, Q. Zhang, and J. Xu for advice, discussion, and critical review of the manuscript. Funding: This work was supported by US Department of Defense Congressionally Directed Medical Research Programs (W81XWH1910524 to X.C., W81XWH1910035 to X.

Sep 8, 2023 | science.org | Xiangdong Lv |Moritz Peiseler |Guojun He |Xuan Lu

Published In ScienceVolume 381 | Issue 66628 September 2023Article versionsSubmission historyReceived: 24 November 2021Accepted: 28 July 2023Published in print: 8 September 2023PermissionsRequest permissions for this article. AcknowledgmentsWe thank J. Rosen, Q. Zhang, and J. Xu for advice, discussion, and critical review of the manuscript. Funding: This work was supported by US Department of Defense Congressionally Directed Medical Research Programs (W81XWH1910524 to X.C., W81XWH1910035 to X.