Jin Cao

Nov 6, 2024 | digitalcommons.library.tmc.edu | Xiangdong Lv |Xuan Lu |Jin Cao |Qin Luo

AbstractDespite substantial advances in targeting mutant KRAS, tumor resistance to KRAS inhibitors (KRASi) remains a major barrier to progress. Here, we report proteostasis reprogramming as a key convergence point of multiple KRASi-resistance mechanisms. Inactivation of oncogenic KRAS down-regulated both the heat shock response and the inositol-requiring enzyme 1α (IRE1α) branch of the unfolded protein response, causing severe proteostasis disturbances.

Jun 6, 2024 | arxiv.org | Jin Cao |Chang Yu

arXiv:2406.04466 (cs) View PDF HTML (experimental) Comments: Subjects: Human-Computer Interaction (cs.HC) Cite as: arXiv:2406.04466 [cs.HC] (or arXiv:2406.04466v1 [cs.HC] for this version) Submission history From: Jin Cao [ view email] [v1] Thu, 6 Jun 2024 19:44:50 UTC (8,952 KB) Bibliographic Tools Bibliographic Explorer Toggle Bibliographic Explorer () Litmaps Toggle Litmaps (What is Litmaps?) scite.ai Toggle scite Smart Citations (What are Smart Citations?) Code, Data, Media Links to Code...