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Nov 6, 2024 | 
digitalcommons.library.tmc.edu | Xiangdong Lv |Xuan Lu |Jin Cao |Qin Luo
AbstractDespite substantial advances in targeting mutant KRAS, tumor resistance to KRAS inhibitors (KRASi) remains a major barrier to progress. Here, we report proteostasis reprogramming as a key convergence point of multiple KRASi-resistance mechanisms. Inactivation of oncogenic KRAS down-regulated both the heat shock response and the inositol-requiring enzyme 1α (IRE1α) branch of the unfolded protein response, causing severe proteostasis disturbances.
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Sep 8, 2023 | 
science.org | Xiangdong Lv |Moritz Peiseler |Guojun He |Adriano Aguzzi
There are no cures for the most common neurodegenerative diseases. None of the currently approved treatments cure or halt these conditions; rather, they address symptoms or slow disease progression. A focus on protein deposits in the brain—a hallmark of Alzheimer’s disease (AD) and Parkinson’s disease (PD)—has led to the development of immunotherapy drugs. Other promising avenues of investigation include the roles of neuroinflammation in neurodegeneration.
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Sep 8, 2023 | 
sciencemag.org | Xiangdong Lv |Moritz Peiseler |Guojun He |Bruna Araujo David
Published In ScienceVolume 381 | Issue 66628 September 2023Article versionsSubmission historyReceived: 13 April 2022Accepted: 13 July 2023Published in print: 8 September 2023PermissionsRequest permissions for this article. AcknowledgmentsWe thank L. Zbytnuik, M. Newton, and T. Nussbaumer for excellent technical support. We thank K. Poon for assistance with flow cytometry. We thank all current and past Kubes lab members for constant support and feedback. The authors thank L. Babes for help with IVM.
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Sep 8, 2023 | 
science.org | Xiangdong Lv |Moritz Peiseler |Guojun He |Bruna Araujo David
Published In ScienceVolume 381 | Issue 66628 September 2023Article versionsSubmission historyReceived: 13 April 2022Accepted: 13 July 2023Published in print: 8 September 2023PermissionsRequest permissions for this article. AcknowledgmentsWe thank L. Zbytnuik, M. Newton, and T. Nussbaumer for excellent technical support. We thank K. Poon for assistance with flow cytometry. We thank all current and past Kubes lab members for constant support and feedback. The authors thank L. Babes for help with IVM.
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Sep 8, 2023 | 
science.org | Xiangdong Lv |Moritz Peiseler |Guojun He |Yuhang Pan
Research ArticleGREEN NUDGESPlastic waste is a global threat that endangers marine and freshwater ecosystems worldwide (1–3). In 2021, more than 400 million metric tons of plastic waste were produced worldwide, and it is predicted that the world’s plastic waste growth will continue to outpace the efforts to reduce plastic pollution in the coming decades (3).
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Sep 8, 2023 | 
sciencemag.org | Xiangdong Lv |Moritz Peiseler |Guojun He |Yuhang Pan
Research ArticleGREEN NUDGESPlastic waste is a global threat that endangers marine and freshwater ecosystems worldwide (1–3). In 2021, more than 400 million metric tons of plastic waste were produced worldwide, and it is predicted that the world’s plastic waste growth will continue to outpace the efforts to reduce plastic pollution in the coming decades (3).
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Sep 8, 2023 | 
sciencemag.org | Xiangdong Lv |Moritz Peiseler |Guojun He |Xuan Lu
Published In ScienceVolume 381 | Issue 66628 September 2023Article versionsSubmission historyReceived: 24 November 2021Accepted: 28 July 2023Published in print: 8 September 2023PermissionsRequest permissions for this article. AcknowledgmentsWe thank J. Rosen, Q. Zhang, and J. Xu for advice, discussion, and critical review of the manuscript. Funding: This work was supported by US Department of Defense Congressionally Directed Medical Research Programs (W81XWH1910524 to X.C., W81XWH1910035 to X.
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Sep 8, 2023 | 
science.org | Xiangdong Lv |Moritz Peiseler |Guojun He |Xuan Lu
Published In ScienceVolume 381 | Issue 66628 September 2023Article versionsSubmission historyReceived: 24 November 2021Accepted: 28 July 2023Published in print: 8 September 2023PermissionsRequest permissions for this article. AcknowledgmentsWe thank J. Rosen, Q. Zhang, and J. Xu for advice, discussion, and critical review of the manuscript. Funding: This work was supported by US Department of Defense Congressionally Directed Medical Research Programs (W81XWH1910524 to X.C., W81XWH1910035 to X.
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Sep 7, 2023 | 
sciencemag.org | Xiangdong Lv |Moritz Peiseler |Guojun He |Xin-Feng Wei
Get full access to this articleView all available purchase options and get full access to this article. References and Notes1Copernicus Climate Change Service, “Surface air temperature for July 2023” (2023); https://climate.copernicus.eu/surface-air-temperature-july-2023. 2U. W. Gedde, M. S. Hedenqvist, M. Hakkarainen, F. Nilsson, O. Das, Applied Polymer Science (Springer, 2021). 3N. Merah, F. Saghir, Z. Khan, A. Bazoune, Plast. Rubber Compos. 35, 226 (2006). 4B. Singh, N. Sharma, Polym. Degrad. Stab. 93, 561 (2008).
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Sep 7, 2023 | 
science.org | Xiangdong Lv |Moritz Peiseler |Guojun He |Seth Scanlon
Research HighlightsImmunometabolism Does chitin help metabolic health? Seth Thomas ScanlonOpen in viewerChitin (β-1,4-poly-N-acetylglucosamine) is a highly abundant natural polysaccharide found in arthropods and fungi that can initiate type 2 (allergic) immune responses. Kim et al. report in mice that the consumption of chitin triggers gastric distension, downstream neuropeptide release, and type 2 cytokine production by tuft cells and type 2 innate lymphoid cells.
