Qixiang Geng

Jan 28, 2025 | pubs.acs.org | Woong Sub Byun |Qixiang Geng |Zixuan Jiang |Katherine A. Donovan

Jan 28, 2025 | dx.doi.org | Woong Sub Byun |Qixiang Geng |Zixuan Jiang |Katherine A. Donovan

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Oct 1, 2024 | biorxiv.org | Woong Sub Byun |Qixiang Geng |Zixuan Jiang |Katherine A. Donovan

AbstractMolecular glue degraders (MGDs) are small molecules that facilitate proximity between a target protein and an E3 ubiquitin ligase thereby inducing target protein degradation. Glutarimide-containing compounds are MGDs that bind to cereblon (CRBN) and recruit neosubstrates. Through explorative synthesis of a glutarimide-based library, we discovered a series of molecules that induce casein kinase 1 alpha (CK1α) degradation.